Angioimmunoblastic T-cell lymphoma: the many-faced lymphoma
نویسندگان
چکیده
منابع مشابه
Angioimmunoblastic T-cell lymphoma
The lymphoma cell is a peripheral T lymphocyte in various stages of differentiation. The neoplastic clone expresses T-cell antigens and is usually CD4+. The malignant T-cells are believed to secrete cytokines responsible for the polyclonal B-cell hyperplasia observed in involved nodes. Clonality studies demonstrated a monoclonal rearrangement of the bchain of the T-cell receptor (TCR) in the ma...
متن کاملAngioimmunoblastic T-cell lymphoma management.
Angioimmunoblastic T-cell lymphoma (AITL) is a frequent subtype of peripheral T-cell lymphoma (PTCL) that is clinically characterized by generalized lymphadenopathy, extranodal involvement, advanced stage at presentation, hypergammaglobulinemia, and significant immune dysregulation resulting in infections as the most common cause of death. Recent advances in pathobiology of AITL have improved o...
متن کاملConjunctival Angioimmunoblastic T-Cell Lymphoma.
Angioimmunoblastic T-cell lymphoma (AITL) represents an uncommon variant of T-cell lymphomas and most often presents insidiously with systemic symptoms. This report constitutes the first documented case of conjunctival AITL, masquerading as nodular episcleritis, and describes both the clinical and pathological findings. Furthermore, conjunctival T-cell lymphoma in general remains a rare occurre...
متن کاملAngioimmunoblastic T-Cell Lymphoma: A Diagnostic Challenge
Angioimmunoblastic T-cell lymphoma (AITL) accounts for 15-20% of all peripheral T-cell lymphomas. It is a rare subtype of CD4 T-cell peripheral lymphoma that affects aged individuals, causing B symptoms, generalized lymphadenopathy and hepatosplenomegaly. Its pathogenesis is still unclear, but in some cases it has been associated with infection, allergic reaction or drug exposure. The majority ...
متن کاملPrimary cerebral angioimmunoblastic T-cell lymphoma.
Case Report A 71-year-old woman with a past medical history of chronic alcoholism and depression presented with a subacute confusional state and was admitted to the Department of Neurology (Hôpital Pierre Wertheimer, Bron, France) in November 2008. At admission, the patient was somnolent, apathetic, and confused. Her spatiotemporal orientation and cognitive function were impaired. She suffered ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Blood
سال: 2017
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2016-09-692541